CD34 and Pearson syndrome: Despite the possibility of spontaneous recovery from anemia in some patients with Pearson syndrome, others may require transfusions during infancy and early childhood.347 Hematopoietic stem cell transplantation is a potential option for those with persistent transfusion dependency or severe neutropenia.347,365 Additionally, mitochondrial augmentation therapy—where autologous CD34+ hematopoietic cells are augmented with maternally derived healthy mitochondria—has shown promising outcomes for mtDNA deletion syndromes like Pearson syndrome and Kearns-Sayre syndrome.