DNM1L and anemia (phenotype): The abnormal iron deposit is a feature in patients with Pearson syndrome, while the molecular mechanisms behind abnormal iron metabolism remain unclear.359 In a mouse model of large-scale mtDNA deletion, Pearson syndrome-like anemia worsened with the knockout of Drp1, and Drp1 knockout alone also caused anemia.359 Drp1 knockout decreases the pathogenic threshold of mtDNA deletion in erythrocytes,359 which drives us to think about the role of MQC in this anemia.