While this observation could reflect practice effects (which occur even when using alternating RBANS versions; Calamia et al., 2012) or could be influenced by the relatively high education level in the sample (Samson et al., 2023), this finding suggests that the absence of the APOE4 allele combined with lower precuneus activity represents a low-risk profile for cognitive decline. This evidence concerns the gene APOE and Mental deterioration.