MPPE1 and neoplasm: A key determinant is antigen specificity, and although dendritic cells are classically described as the archetypal APC, other stromal cells including macrophages and fibroblasts are capable of presenting antigens.25 26 Among dendritic cell subtypes, conventional dendritic cell type-1 (cDC1) have been shown to be crucial for driving T cell priming in the tumour setting.27 28 However, in established PDAC there are fewer cDC1s, which are dysfunctional and fail to stimulate antitumour immunity.29 30