MTHFR and obesity due to melanocortin 4 receptor deficiency: Similarly, the dysregulation of other enzymes and proteins involved in DNA methylation dynamics, such as the ten‐eleven translocation (TET) proteins, fat mass and obesity‐associated (FTO) protein, and methylenetetrahydrofolate reductase (MTHFR) enzyme, can disrupt the epigenetic landscape in HFrEF.