For patient 328 (CRC at 41 years and breast cancer at 54 years), ddPCR analysis confirmed the presence of the MSH2 c.1413del p.Lys471Asnfs*11 somatic variant in the CRC (67.4% variant allele frequency [VAF]) in the normal adjacent tissue (0.5% VAF) and in the normal nonadjacent tissue 120 mm away from the CRC (0.2% VAF). Here, MSH2 is linked to colorectal carcinoma.