Furthermore, the GO cellular response to heat gene expression signature that is associated with oncogenic AR signaling and poorer prognosis in patients with advanced prostate cancer, also significantly associated with Hallmark E2F Targets in PCF-SU2C (r = 0.77, P < 0.001) and ICR-RMH (r = 0.79, P < 0.001) CRPC transcriptome cohorts (Fig. 3H; refs. 2, 48). The gene discussed is AR; the disease is Familial prostate cancer.