BRCA2 and breast cancer: In silico analysis results showed that the 14 overlapping genes may be associated with many important transcription factors including TP53 and MYC, BRCA1, BRCA2, FOXO1 etc. (Fig 1D). The results suggest that because alterations to the expression of 14 genes can affect the expression of many transcription factors, further research into the roles of these genes in BC processes may be critical in understanding the molecular mechanisms underlying disease initiation and development.