In this study, MVMR was employed to address endogeneities and provide causal estimation regarding the relationship existing between HOA and stroke, while adjusting for the influence of hypertension, alcoholic drinks per week, Cigarettes per Day, Type 2 diabetes (T2D),C-reactive protein (CRP), body mass index (BMI), and rheumatoid arthritis. The gene discussed is CRP; the disease is rheumatoid arthritis.