Although the majority of ING5 KO and WT animals unaffected by dermatitis had similar lifespans, living to, on average 130 weeks, 13.1% of ING5 KO animals (17 of 129) versus 2.3% of WT animals (3 of 132) that were 18 months or older developed enlarged lymph nodes, spleens and pancreata as shown in (Fig 9), and were subsequently euthanized. The gene discussed is ING5; the disease is skin disorder.