Therefore, our aim is to explore the association of NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2 (rs105193, rs1805017), APOE (rs429358, rs7412), PCSK9 (rs505151), MEF2A (rs325400), and LDLR (rs1122608, rs2228671) in families affected by CAD within the Pakistani population. The gene discussed is APOE; the disease is coronary artery disorder.