Polymorphisms in genes such as NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2 (rs105193, rs1805017), APOE (rs429358, rs7412), PCSK9 (rs505151), MEF2A (rs325400), and LDLR (rs1122608, rs2228671) related to CAD have been studied. This evidence concerns the gene PCSK9 and coronary artery disorder.