Therefore, our aim is to explore the association of NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2 (rs105193, rs1805017), APOE (rs429358, rs7412), PCSK9 (rs505151), MEF2A (rs325400), and LDLR (rs1122608, rs2228671) in families affected by CAD within the Pakistani population. This evidence concerns the gene LDLR and coronary artery disorder.