But our research is unique as it is the first study focusing on NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2 (rs105193, rs1805017), APOE (rs429358, rs7412), PCSK9 (rs505151), MEF2A (rs325400), and LDLR (rs1122608, rs2228671) to investigate different genetic variants, pattern of inheritance and their relation with CAD specifically in families in Pakistan. Here, APOE is linked to coronary artery disorder.