Therefore, our aim is to explore the association of NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2 (rs105193, rs1805017), APOE (rs429358, rs7412), PCSK9 (rs505151), MEF2A (rs325400), and LDLR (rs1122608, rs2228671) in families affected by CAD within the Pakistani population. Here, PON1 is linked to coronary artery disorder.