With respect to the cancer group, the upregulation of mir-195-3p, KLK11, A1AG2, SMIM1, and the downregulation of mir-3176, mir-205-5p, novel-hsa-mir-208-3p, mir-3529-3p and let-7i-3p, CXCL7, TBB1, ACTN1 and BIP were identified compared with the non-cancer group. The gene discussed is SMIM1; the disease is cancer.