TPO and follicular thyroid adenoma: Previous studies of sEVs showed that a panel of five miRNAs could discriminate follicular adenoma (FA) from FTC with an AUC of 0.92434, while another study35 identified two miRNAs of the Let-7 family (Let-7f and Let-7d) to be overexpressed in a subgroup of plasma sEVs expressing thyroid peroxidase (TPO) that potentially can discriminate FA from FTC35,36.