Nevertheless, Eijsvogels et al. (2012) reported that after a 30-, 40- and 50-km walk, the magnitude of absolute cTnI increase was comparable among lean, overweight, and individuals with obesity, suggesting that exercise intensity (i.e. as a percentage of HRMAX), rather than anthropometric factors, was the most important predictor of cTnI release after a long endurance event. This evidence concerns the gene TNNI3 and obesity due to melanocortin 4 receptor deficiency.