A previous study found that albumin, a plasma protein, correlated with the number of differentially abundant CSF proteins.30 Blood-brain barrier disruption-associated CSF proteins also correlated with poorer survival in brain metastases and CNS lymphomas.30 Intra-operative microdialysis in gliomas demonstrated higher plasma-derived metabolite levels in regions with BBB disruption compared with intact areas of the tumor.42 Thus, BBB disruption may contribute to the glioma proteome. Here, ALB is linked to primary central nervous system lymphoma.