A previous study found that albumin, a plasma protein, correlated with the number of differentially abundant CSF proteins.30 Blood-brain barrier disruption-associated CSF proteins also correlated with poorer survival in brain metastases and CNS lymphomas.30 Intra-operative microdialysis in gliomas demonstrated higher plasma-derived metabolite levels in regions with BBB disruption compared with intact areas of the tumor.42 Thus, BBB disruption may contribute to the glioma proteome. The gene discussed is ALB; the disease is glioma.