Therapeutic agents effective in preventing HF by affecting one or more of these mechanistic pathways include diuretics, angiotensin‐converting enzyme and angiotensin receptor inhibitors, beta‐adrenergic receptor blockers, mineralocorticoid receptor antagonists, statins, and Na+‐glucose co‐transporter 2 (SGLT2) inhibitors [30, 31, 32, 33, 34, 35, 36]. The gene discussed is SLC5A2; the disease is hydrops fetalis.