CTCF and head and neck squamous cell carcinoma: TBG significantly inhibited the protein expression of PLK1 in HNSCC cells, thereby suppressing the expression of G2/M phase‐associated proteins including CDK1, CDC25c, and Cyclin B1, while the inhibited PLK1 was unable to promote nuclear ectasia of CTCF, thus inhibiting the metastasis of HNSCC cells.