Cyclopamine also blocked the growth of androgen‐dependent parental LNCaP cells and cell growth was restored when supplemented with androgens in the presence of cyclopamine.[13] Our research showed overexpression of circ_0 005185 increased RAB8A levels in prostate cancer cells, thereby promoting ciliogenesis and inhibiting Hh signaling pathway activation. The gene discussed is RAB8A; the disease is prostate cancer.