Recent research has also found that OTUB1 maintains low levels of PD‐L1 ubiquitination, indicating its potential as a target in immune evasion related to PD‐L1/PD‐1 therapy and in the immunosuppression of cancer cells.[32, 33] However, the interaction between OTUB1 and RAB8A in prostate cancer cells, and the role of circRNAs in this context, has not been reported. This evidence concerns the gene RAB8A and cancer.