OTUB1 and urinary bladder carcinoma: Studies have indicated that OTUB1 promotes bladder cancer development by stabilizing and deubiquitinating ATF6.[30] Additionally, OTUB1 plays a crucial role in immune responses where it can inhibit AKT by removing ubiquitin, consequently disrupting its association with the cell membrane, which may impair the connection between AKT and PIP3.[31] The inhibition of OTUB1 could stimulate robust immune‐related responses and serve as a clinical target for T‐cell therapy, suggesting that increasing OTUB1 expression may help suppress abnormal immune reactions.