CX3CL1 and cancer: To investigate the mechanism by which CX3CL1 mediates T‐cell exhaustion, we calculated the cancer‐immunity cycle score (CICS) (http://biocc.hrbmu.edu.cn/TIP/)[15] using mRNA expression data for the 28 samples with the highest CX3CL1 expression and the 28 samples with the lowest CX3CL1 expression among TCGA CRC samples.