SIRT1 and neoplasm: Our previous studies revealed that the deacetylase SIRT1, which is widely distributed in the cytoplasm and nucleus, is a metabolic switch between glycolysis and fatty acid oxidation, its upregulation enables tumor cells to adapt to glucose deprivation and promotes tumor progression.[3] Given that high SIRT1 expression in tumor cells can affect the expression and secretion of cytokines, thus influencing tumor growth and metastasis, further exploration of whether SIRT1 inhibits tumor immunity is warranted.[4]