Through transcription factor analysis via a single‐cell CRISPR screening system, the RBPJ‐IRF1 axis was shown to drive terminal differentiation toward exhausted cell phenotypes.[25] However, major knowledge gaps remain regarding the gene regulatory networks and corresponding differentiation directions that govern other immunosuppressive cells, such as Tregs, tumor‐associated macrophages, and MDSCs. The gene discussed is IRF1; the disease is neoplasm.