CX3CL1 and neoplasm: However, CX3CL1 participates in tumor invasion and metastasis in some tumors, leading to a poor prognosis.[5] Recent studies have indicated that the interaction between tumor cells and other cells in the microenvironment mediated by CX3CL1, such as macrophages and mesenchymal stem cells, is related to developing an immunosuppressive environment.[6, 7] Therefore, a comprehensive analysis of the mechanism of CX3CL1 production and function contributes to unraveling its effector network in TME.