KRT5 and keratoconus: Two different models have been proposed during cutaneous wound reepithelization for KC migration: (a) migrating Keratin 5+ (KRT5+) basal KCs move into the wound bed and transform into suprabasal KCs in a unidirectional manner, and (b) epidermal cells in the wound periphery migrate into the wound bed by crawling or leaping over one another and then dedifferentiate to form basal cells (45, 46).