CXCL1 and CXCL5 regulate myeloid recruitment, activation, and polarization; to assess whether KRASG12D-mediated TCM or fibroblast cytokine secretion plays a role in the polarization of macrophages, we isolated and differentiated BMDMs from control mice and cultured them in TCM or FB CM from ON, OFF, and MRTX-treated LC3-547 lung cancer cells or fibroblasts for 6 days (Figure 6G). This evidence concerns the gene CXCL1 and lung carcinoma.