As expected from the bulk RNA-sequencing data showing an increase in Cxcl2 and Cxcl5 expression after FF-10101 treatment (Supplemental Figure 8B), there was a trend toward an increasing frequency of PMN-MDSC (CD45+CD11b+F4/80–Ly6G+Ly6C–) population in the TME after FF-10101 treatment; however, the extent of the PMN-MDSC population varied in mice bearing different tumor cell lines (Supplemental Figure 11A). Here, CXCL2 is linked to neoplasm.