The results indicated that CD14+ CD16+ monocyte absolute count, CD14+ CD16+ monocyte %monocyte (The proportion of CD14+ CD16+ monocytes among monocytes), and CD20 on IgD+ CD38^dim B cells (CD20 expression level on IgD+ CD38^dim B cells) may act as mediators of the protective effect of a GFD on RA. This evidence concerns the gene CD14 and rheumatoid arthritis.