In addition, Roudier et al.27 reported that the protein level of DCLK1 was greater in unpaired CRPC metastases tissues than in primary PCa tissues and that compared with DCLK1- patients, DCLK1+ patients exhibited a shorter time to biochemical recurrence, suggesting that DCLK1 plays a crucial role in the progression of primary PCa to metastatic CPRC. The gene discussed is DCLK1; the disease is posterior cortical atrophy.