MTHFR and idiopathic scoliosis: In this study, 23 of 44 patients with a history of idiopathic scoliosis had a positive MTHFR variant (defined as homozygous A1298C, homozygous C677T, or heterozygous for both C677T and A1298C) versus 11 of the 44 patients in the control group (P < 0.01)12.