Other factors implicated in the rapid progression of AIS are SOX9 and KCNJ2 variants, Lenke type 4 curves associated with gene loci 6q24 and 10q24, microRNA 4300 genes, increased calmodulin levels, decreased melatonin levels, and a positive ScoliScore26. This evidence concerns the gene SOX9 and androgen insensitivity syndrome.