Tryptophan hydroxylase (TPH1 rs10488682), insulin-like growth factor (IGF1 rs5742612), neurotrophin 3 (NTF3 gene promoter at rs11063714), interleukin-17 receptor C (IL17RC rs708567), melatonin receptor 1B (MTNR1B rs4753426) were identified as risk factors for scoliosis curve progression27. Here, IL18RAP is linked to scoliosis.