GPT and Hepatic fibrosis: Overexpression of TINAGL1 exacerbated the progression of liver fibrosis, showing higher positive areas of Masson and Sirius red (Figure 6E andFigure S5B), higher serum levels of AST and ALT (Figure 6F), and higher content of hydroxyproline (Figure 6G) compared to the AAV8-Control group, in parallel with a significant increase in liver / body weight ratio (Figure 6H), without affecting body weight (Figure S5C).