Although the activation of caspase 2 induces apoptotic cell death in cancer cells by caspase 3 dependent as well as independent pathways 43, 44, cell death induced by Super-EBS is prevented by the caspase 2 inhibitor but not caspase 3 inhibitor, implying that caspase 3 activation is dispensable and caspase 2 activation is essential for the growth inhibitory action of Super-EBS. This evidence concerns the gene CASP3 and cancer.