Given that inhibition of dNTP synthesis by anticancer drugs enhances double-strand breaks (DBSs) 10 and downregulation of GLDC inhibited dNTP synthesis and increased the expression of SETD2 that facilitates and repairs DSBs in RCC cells 32, we reasoned that GLDC might play a role in the cellular response to DNA damage. Here, GLDC is linked to renal cell carcinoma.