A recent study suggested that ISGF level is commonly regulated by polybromo 1 (PBRM1), SET domain containing 2 (SETD2), lysine demethylase 5C (KDM5C), and BRCA1 associated protein 1 (BAP1), tumor suppressor genes that are secondarily mutated in RCC after VHL (von Hippel-Lindau) inactivation 18. Here, KDM5C is linked to renal cell carcinoma.