Therefore, we proposed that FKBP10 facilitated BC cells invasion and migration by downregulating lamin A. Indeed, wound healing and transwell assays showed that lamin A knockdown partially blocked the reduced migration and invasion induced by FKBP10 knockdown (Fig. 6B-D). Even in the Transwell assay with smaller-pore (3 and 5 μm) chambers, the downregulation of lamin A could partially restore the impaired migration ability of BC cells resulted from FKBP10 knockdown (Fig. 6D). The gene discussed is FKBP10; the disease is breast cancer.