ROBO2 and fibrosis: Wang et al. have found that roundabout guidance receptor 2 (ROBO2) is a novel susceptibility gene for pediatric patients with cardiovascular toxicity, which promotes cardiac fibrosis through the Slit-Robo-Smad pathway, leads to disordered remodeling of extracellular matrix and exacerbates heart failure, suggesting that genetic factors will be an important basis for risk stratification in the future 17.