Interestingly, we observed an increase in CDK8 and MED12 expression with bleomycin treatment in vivo (Figure 8K), as well as increased CDK8 expression in IPF patients (Figure 1D, E), whereas in cell experiments, treatment with TGFβ did not increase the expression of CDK8 or MED12 (Figure 4E). This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.