Results presented that E966-0530-45418 attenuated myofibroblast formation and collagen deposition in lung cells through inhibition of TGFβ1/Smad signaling and reduced M2 macrophages polarization by obstacle of STAT3 signaling; moreover, E966-0530-45418 ameliorated lung function decline in bleomycin-induced PF mouse model. This evidence concerns the gene TGFB1 and pemphigus foliaceus.