Notably, the top ten pathways identified through GSEA data indicated the strongest correlations with fatty acid metabolism and adipogenesis, suggesting that LPCAT1 may alter lipid droplet accumulation in ccRCC via regulating fatty acid metabolism (Fig. 4B-C) Subsequently, we used a fatty acid assay kit to assess sh-LPCAT 786-O and A-498 cells. Here, LPCAT1 is linked to nonpapillary renal cell carcinoma.