PIEZO1 and Hepatic steatosis: In conclusion, this study showed IEC PIEZO1 was downregulated in human and mice with MASLD, confirmed that genetic reduction of IEC PIEZO1 ameliorated liver steatosis via blocking retinol metabolism and FGF15 production, and highlighted IEC PIEZO1 as a promising target for therapy of hepatic steatosis via the gut-liver axis.