Similarly, overexpression of CYP7A1 in a mice MASLD model effectively alleviated hepatic steatosis via activation of the hepatic BAs signaling pathway, inhibition of lipid synthesis, and decreased fatty acid uptake39-41, which was consistent with the downregulation of genes related to fatty acid transport and synthesis in Piezo1ΔIEC mice liver in this study. Here, CYP7A1 is linked to fatty liver disease.