KLK3 and metastatic malignant neoplasm in the lymph nodes: This association remained robust in multivariate Cox analyses, which accounted for clinical risk factors such as age, PSA levels at diagnosis, pathological stage, Gleason score, surgical margin status, and lymph node metastasis (adjusted HR=1.49, 95% CI=1.12‒1.98, P=0.007; Table 1 and Figure 1C).