Furthermore, the evaluation of univariate cox regression model revealed that low expression of FDX1 (HR 1.971; 95% CI 1.444-2.692, P < 0.001), DLAT (HR 2.422; 95% CI 1.758-3.337, P < 0.001), PDHA1 (HR 1.605; 95% CI 1.183-2.178, P = 0.002), PDHB (HR 1.608; 95% CI 1.183-2.185, P = 0.002) and GLS (HR 1.408; 95% CI 1.041-1.905, P = 0.027) were poor predictors for OS in ccRCC patients (Fig. 3I). This evidence concerns the gene FDX1 and nonpapillary renal cell carcinoma.