We characterized melanoma cells and conducted dimensionality reduction clustering, revealing six distinct cell subgroups: C0 TRPM1+ Melanoma cells, C1 PIR+ Melanoma cells, C2 PHLDA2+ Melanoma cells, C3 ID2+ Melanoma cells, C4 PCLAF+ Melanoma cells, and C5 CD74+ Melanoma cells. This evidence concerns the gene PHLDA2 and melanoma.