If we set all 10 identified cell types in melanoma as the source cells of ARGN, and set the five cell types listed on the left in Figure 9B as potential target cells, then the hierarchical diagram showed that ARGN released by C2 PHLDA2+ Melanoma cells and C4 PCLAF+ Melanoma cells, and both C2 and C4 cells could target melanoma cells expect C3 ID2+ Melanoma cells (Figure 9B). Here, PHLDA2 is linked to melanoma.