PIR and melanoma: In state1, the proportion of C3 ID2+ Melanoma cells subgroup was the highest, while in state2, state4 and state5, the proportion of C2 PHLDA2+ Melanoma cells subgroup was the highest, and in state3, the proportion of C0 TRPM1+ Melanoma cells subgroup was the highest, and in state6, the proportion of C4 PCLAF+ Melanoma cells subgroup was the highest, and C1 PIR+ Melanoma cells subgroup only existed in state7.