We found that TGFb can be secreted by immune cells (T_NK cells, B_Plasma cells, Myeloid cells), ECs, Fibroblasts, C2 PHLDA2+ Melanoma cells, C4 PCLAF+ Melanoma cells and C5 CD74+ Melanoma cells, and targeting C2 PHLDA2+ Melanoma cells and C4 PCLAF+ Melanoma cells (Figure 9J-M). This evidence concerns the gene PHLDA2 and melanoma.