In order to screen the key genes of lasalocid inhibiting melanoma, we combined the down-regulated genes treat with lasalocid (DEGs down), the genes highly expressed in melanoma in the TCGA database (TCGA SKCM), and the genes related to the survival of melanoma patients in the TCGA database (Survival OS), and we identified six candidate genes: EVIEVI2B, LAPTM5, FOXM1, CXCL10, CORO1A and SELPLG (Fig. 4D). The gene discussed is LAPTM5; the disease is melanoma.