Herein, the GEPIA database was used to visualize the expression level of the HIF-1α gene in multiple tumors, which revealed significant overexpression of HIF-1α in ESCA, GBM, HNSC, LAML, LGG, PAAD, STAD and other tumors compared to normal controls (Figure 1A). This evidence concerns the gene HIF1A and glioblastoma.