In subgroup analyses, there was a significant difference between the wild-type and mutant pattern (P<0.001) in terms of distant metastasis (Table 3); there was a significant difference between the p53 wild-type and p53 mutant pattern (P<0.001) in pN0 and pN+ gastric carcinomas (P<0.001 and P=0.014, respectively). This evidence concerns the gene TP53 and gastric carcinoma.