Deficiencies in MAGT1 lead to significant glycosylation defects and altered expression of genes involved in CD28 immune mechanism,59 with MAGT1 knock-out in mice resulting in increased frequency of CD19+ B lymphocytes.60 Glycoprotein quantification has been recently applied in the diagnosis and prognosis neurodegenerative diseases.61 Here, MAGT1 is linked to neurodegenerative disease.