Specifically, meR316-ALKBH5 expression, tumor diameter, differentiation, TNM stage, depth of invasion, lymph node metastasis, and metastasis were found to be important predictive variables for the overall survival (OS) and disease-free survival (DFS) of patients with CRC according to univariate Cox regression analysis (Table S5). This evidence concerns the gene ALKBH5 and metastatic malignant neoplasm in the lymph nodes.