Anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody is known to be present in several endocrine autoimmune disorders like diabetes mellitus and thyroid disease [1]. Several neurologic syndromes have been linked to this antibody as well, such as autoimmune encephalitis presenting as epilepsy, Miller Fisher syndrome (MFS), and stiff-person syndrome (SPS) with some of these reporting ophthalmoplegia [2-6]. A case of isolated ophthalmoplegia associated with positive anti-GAD antibody titers was reported in 2021; however, this patient developed global ataxia later in the disease course [7]. The gene discussed is GAD2; the disease is stiff-person syndrome.