Recently, we have shown that TNFα induced the expression of CCL2 and CCL5 in ST2 cells (Panahipour et al. 2022; Kargarpour et al. 2023). Moreover, CCL2 and CCL5 are elevated in gingival crevicular fluid in patients with generalized aggressive periodontitis (Emingil et al. 2004). The gene discussed is CCL5; the disease is periodontitis, aggressive.