It is speculated that MMP‐3 may become a therapeutic target for IDD [11]; MMP‐7 induces MMP‐3 through mediation, and MMP‐3 is necessary for the production of macrophage chemokines and subsequent macrophage infiltration of the intervertebral disc leading to IDD [12]; MMP‐10 mRNA and IDD also show a significant correlation in cadaver samples [13]; The results of animal experiments on MMP12 show that it will affect the homeostasis of intervertebral disc cells and may lead to IDD [14]. This evidence concerns the gene MMP3 and intervertebral disk degenerative disorder.