For example, MMP‐1 immunohistochemical scores in IDD tissues of patients after lumbar spine surgery show an independent correlation with histological degeneration scores in patients with cervical or lumbar IDD, indicating that MMP‐1 immunohistochemical scores can be used as an indicator of IVD degeneration [10]; In degenerated intervertebral disc tissue, MMP‐3 is significantly correlated with the histopathological changes of expressing intervertebral discs, and there is no correlation between MMP‐3 expression and age, gender, and pain duration. This evidence concerns the gene MMP3 and intervertebral disk degenerative disorder.