ITGAE and neoplasm: Notably, we revealed that rM-FC could upregulate the number of mature dendritic cells in tumor-draining lymph nodes (TDLNs), activate intratumoral effector T cells, increase the presence of CD103+ DCs within the treated tumor, facilitate the transition of anti-inflammatory macrophages (M2) to pro-inflammatory macrophages (M1), and upgrade the expression of various effector cytokines (Fig. 1).