Patients with PDW ≥ 14.3 fL presented a multivariate-adjusted HR of death of 1.32 (95% CI: 1.05–1.64, P = .2) independent of age, sex, CAD, noncoronary atherosclerotic disease, DM, inflammatory/autoimmune disease, NYHA class, LVSD severity, chronic kidney disease, BNP, and evidence-based therapy. This evidence concerns the gene NPPB and chronic kidney disease.