REN and glomerular disorder: In conclusion, glomerular disease can cause damage to the glomerular endothelial cell in many structures and pathways (complement system; angiogenesis-related factors; renin-angiotensin system; endothelin complex; coagulation cascade; interaction between these pathways; interactions between glomerular structures and interstitial structures), which may represent different potential therapeutic targets to explore in the case of vascular damage associated with glomerular diseases, in particular TMA.