In TMA, especially in aHUS, and C3 glomerulopathy, genetic sequencing studies have contributed to the identification of genetic variants involved in the complement pathways, such as: CFH, CFI, MCP/CD46, complement factor B (CFB), thrombomodulin (THBD), C3 and others (56, 57). The gene discussed is C3; the disease is complement 3 glomerulopathy.