Additionally, 25.6% (95% CI: 16.2%, 38.1%), 10.1% (95% CI: 4.6%, 20.9%), 15.5% (95% CI: 7.9%, 28.2%), 10.1% (95% CI: 4.7%, 20.5%), 8.1% (95% CI: 3.9%, 16.0%), 11.6% (95% CI: 5.0%, 24.8%), 9.6% (95% CI: 3.7%, 22.5%), 4.8% (95% CI: 2.0%, 11.2%), and 3.0% (95% CI: 1.1%, 8.1%) of the social isolation–NAFLD association were statistically significantly mediated through unhealthy lifestyle score, obesity, current smoking, irregular physical activity, suboptimal sleep duration, depression, CRP, count of white blood cells, and count of neutrophils, respectively (Table 3). The gene discussed is CRP; the disease is major depressive disorder.