STAT3 and breast cancer: TDE cargo also contributes to inflammatory processes; for example, Annexin A2 in TDEs released from breast cancer tissue is responsible for the activation of several signaling pathways, including the p38 mitogen-activated protein kinase (MAPK), nuclear factor κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3) pathways within the cell.