Assuming the protein coded by △(E8p24) is functional, and noting that this variant has been observed in Li-Fraumeni syndrome individuals according to multiple ClinVar submissions, it is reasonable to assume that an aberrant transcript expression of at least ~ 50% might be enough to negatively affect TP53 expression and p53 function and predispose to tumorigenesis. Here, TP53 is linked to Li-Fraumeni syndrome.