For EFS the following variables were included to the model: extramedullary AML, HMA pretreatment, mutated PTPN11, FLT3, NF1, and SF3B1. Based on the individual scores patients were stratified into three risk groups for EFS analogous to OS (Supplementary Fig. S6B). This evidence concerns the gene PTPN11 and acute myeloid leukemia.