For OS the following variables were included in the model: extramedullary AML, HMA pretreatment, mutated PTPN11, FLT3, TP53, NF1, and SF3B1. Each variable was weighted by calculating the hazard coefficient, which is the natural logarithm of the hazard ratio of the variable (Table 4). The gene discussed is TP53; the disease is acute myeloid leukemia.