Although our study did not identify a beneficial function of HDAC8-TRAF7 binding in SCs for PNS regeneration, we can speculate that by controlling HIF1α stabilization, the interaction of HDAC8 with TRAF7 may have beneficial effects in preventing neoangiogenesis and thereby the growth of tumors30 such as schwannomas that are more susceptible to develop after a peripheral nerve injury75. Here, HIF1A is linked to schwannoma.